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Gatekeeping Health: Ethical Challenges in Allocating Ozempic

By Raphael Lee

Obesity is a global health crisis with far-reaching consequences, extending beyond individual health to significantly impact social and economic systems worldwide. Obesity is characterized as a complex disease caused by accumulated excess body fat, which leads to negative health impacts [1]. Obesity is associated with numerous comorbidities, including various cancers, cardiovascular events, and other conditions, contributing to over three million deaths annually throughout the world [2]. The healthcare costs linked to obesity place a great strain on systems globally, making it a priority for governments, researchers, and healthcare providers.

The current recommendation to treat obesity emphasizes lifestyle modifications which include dietary changes, increased physical activity, and behavior therapy [3]. The prevalence of obesity is continuously going up along with the adverse health outcomes associated with it [4]. With more than 1 billion people in the world with obesity, alternate research to treat the obesity epidemic has been a top priority [5]. This has led to a surge in research efforts to combat obesity, including the development of pharmaceutical medications like Ozempic, a brand name for semaglutide. While it was originally developed for patients managing type 2 diabetes, semaglutide has demonstrated promising results in aiding weight loss [6]. It aids patients with diabetes as more insulin is released which in turn leads to lower blood sugar levels and have shown promise in clinical trials to facilitate weight loss [7].

Ozempic (semaglutide) belongs to a class of medications known as GLP-1 receptor agonists. GLP-1, or glucagon-like peptide-1, is a hormone naturally produced in the body that plays a key role in regulating blood sugar levels and appetite. By mimicking the effects of this hormone, Ozempic enhances the secretion of insulin in response to meals, and suppresses the release of glucagon. These actions not only help manage blood sugar levels in patients with type 2 diabetes but also promote feelings of fullness, making it effective for weight loss in individuals with obesity.

Despite its intended use for diabetes management, Ozempic gained widespread attention through social media where it was often hailed as a “miracle drug” for weight loss. Many influencers promoted the use of these drugs as short-term methods to lose weight. It has garnered the attention of many people to use off-label for cosmetic purposes leading to a low supply of a highly demanded medication. This shift in usage underscores the ethical, social, and economic dilemmas surrounding the allocation of such a limited and impactful medication.

The popularity of Ozempic for cosmetic purposes which can be seen throughout Hollywood raises ethical questions regarding resource allocation. Even years after its release, the supply of semaglutide remains limited. Given this limitation, priority should be placed on ensuring access for patients with diabetes and obesity-related health conditions. However, the off-label demand for cosmetic weight loss has contributed to shortages, leaving some diabetic patients without access to their prescribed medication [8].

This highlights the issue of healthcare equity. Should medications be prioritized towards people with life-threatening conditions or should physicians also consider psychological well-being such as body image issues? While Ozempic can potentially benefit those facing mental health challenges related to body image, the finite supply necessitates prioritizing patients with critical medical needs. Physicians must balance their duty to provide the best possible care for individual patients with the broader responsibility of prescribing medications ethically and responsibly.

Along with the limitations of a low supply of semaglutide drugs, the high costs for these drugs present a significant challenge. For uninsured individuals, the monthly cost of Ozempic approaches $1,000, creating substantial barriers to access [9]. For uninsured or underinsured individuals, the cost is prohibitive, effectively limiting access to wealthier populations. This creates a disparity where the benefits of Ozempic are disproportionately available to those who can afford it, exacerbating existing health disparities. Marginalized communities, who often bear the highest burden of obesity, are left without access to potentially life-changing treatment [10].

Addressing these financial barriers requires policy reforms and investment in healthcare systems. Governments and healthcare providers must explore solutions to ensure that cost does not become an insurmountable obstacle for those in need. Achieving affordability, however, must not compromise the quality or innovation of treatments.

Ozempic being used as a weight loss drug could also have a significant societal impact regarding weight loss and obesity. On one hand, it challenges the long-standing stigma that obesity results from a lack of willpower and increases recognition of obesity as a complex medical condition. On the other hand, using semaglutide drugs as a quick fix for weight loss risks reinforcing a certain beauty standard overshadowing the importance of addressing the root causes of obesity, such as food insecurity, lack of access to recreational spaces, and systemic inequities.
A holistic approach that combines medical treatments with community-based interventions is essential for sustainable progress. Addressing the social determinants of health, alongside pharmaceutical advancements, can lead to more comprehensive and lasting solutions to the obesity epidemic.

Ozempic represents a groundbreaking achievement in recent years for the treatment of diabetes and obesity. However, its popularity for its use as a weight loss drug highlights the ethical, social, and economic challenges. Addressing these issues requires a multifaceted approach that prioritizes equitable access, responsible prescribing, and societal education about the complexities of obesity. With guidance using ethical principles, semaglutide drugs have the potential for a new age of healthy living while ensuring the benefits are shared equitably.

Review Editor: Emily Walsh

[1] Lin, X., & Li, H. (2021). Obesity: Epidemiology, pathophysiology, and therapeutics. Frontiers in Endocrinology, 12. https://doi.org/10.3389/fendo.2021.706978
[2] Kelishadi, R. (2007). Childhood overweight, obesity, and the metabolic syndrome in developing countries. Epidemiologic Reviews, 29(1), 62–76. https://doi.org/10.1093/epirev/mxm003
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[6] Wilding, J. P. H., Batterham, R. L., Calanna, S., et al. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/nejmoa2032183
[7] Wilding, J. P. H., Batterham, R. L., Calanna, S., et al. (2021). Once-weekly semaglutide in adults with overweight or obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/nejmoa2032183
[8] NBCUniversal News Group. (2023, January 12). People with diabetes struggle to find ozempic as it soars in popularity as a weight loss aid. NBCNews.com. https://www.nbcnews.com/health/health-news/people-diabetes-struggle-find-ozempic-soars-popularity-weight-loss-aid-rcna64916
[9] Willson, A. (2024, November 7). How much does ozempic cost? with & without insurance. Ro. https://ro.co/weight-loss/ozempic-cost-without-insurance/
[10] Candib, L. M. (2007). Obesity and diabetes in vulnerable populations: reflection on proximal and distal causes. Annals of family medicine, 5(6), 547–556. https://doi.org/10.1370/afm.754

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